P50-DE016191-04 Publications

   2007-2008 
 

   Original Reports 

  1. Levy BD, Lukacs NW, Berlin AA, Schmidt B, Guilford WJ, Serhan CN, Parkinson JF. Lipoxin A4 analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J. 2007; 21:3877-84 (Epub July 11; doi: 10.1096/fj.07-8653com).

  2. Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TE. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007; 179:7021-29 (issue cover).

  3. Haas-Stapleton EH, Lu Y, Hong S, Arita M, Favoreto S, Nigam S, Serhan CN, Agabian N. Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator Resolvin E1. PLoS ONE 2007; 2:e1316 (doi:10.1371/journal.pone.0001316). PMCID: 2134765

  4. Masoodi M, Mir AA, Petasis NA, Serhan CN, Nicolaou A. Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2007; 22:75-83 (Epub Dec. 4).

  5. Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CN. Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008; 180:3512-19.

  6. Poulsen RC, Gotlinger KH, Serhan CN, Kruger MC. Identification of inflammatory and pro-resolving lipid mediators in bone marrow and their profile alteration with ovariectomy and omega-3 intake. Am J Hematol. 2008; 83:437-45.

  7. Petasis NA, Keledjian R, Sun Y-P, Nagulapalli KC, Tjonahen E, Yang R, Serhan CN. Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorg Med Chem Lett. 2008; 18:1382-87 (doi:10.1016/j.bmcl.2008.01.013).

  8. Machado FS, Esper L, Dias A, Madan R, Gu YY, Hildeman D, Serhan CN, Karp C, Aliberti J. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med.; published on-line 4/14/08 (doi: 10.1084/jem20072416).

  9. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CN. Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood 2008; prepublished online 5/14/08 (doi: 10.1182/blood-2007-11-122598).

  10. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS ONE 2008; 3:e1879. PMCID: 2268966

  11. Campbell E, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, and Colgan SP:  Resolvin E1 promotes mucosal surface clearance of neutrophils: A new paradigm for inflammatory resolution. FASEB J. 2007; 3162-70.

  12. Kong T, Scully M, Shelley CS, Colgan SP. Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta-2 integrin family. J Immunol. 2007; 179:1934-41.

  13. Robinson A, Keely S, Karhausen J, Gerich ME, Furuta GT, Colgan SP. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology. 2008; 134:145-55. PMCID: 2194638

  14. Louis NA, Robinson AM, Macmanus CF, Karhausen J, Scully M, Colgan SP. Control of IFN-{alpha}A by CD73: Implications for Mucosal Inflammation. J Immunol. 2008;180:4246-55.

  15. Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology. 2008; 134:756-67.

  16. El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, and Van Dyke TE.  Platelet-Rich Plasma: Growth Factors and Pro- and Anti-Inflammatory Properties. J Periodontol Apr;78(4):661-669, 2007.

  17. Herrmann JM, Bernardo J, Long HJ, Seetoo K, McMenamin ME, Batista EL Jr., Van Dyke TE, and Simons ER. Sequential chemotactic and phagocytic activation of human polymorphonuclear neutrophils. Infect Immun. Aug;75(8):3989-98. Epub 2007 May 25, 2007. PMCID: 1952002

  18. Van Dyke TE. Cellular and Molecular Susceptibility Determinants for Periodontitis. Periodontol 2000 (45): 10-13, 2007.

  19. Davé S, Van Dyke T. The link between periodontal disease and cardiovascular disease is probably inflammation. Oral Dis. Mar;14(2):95-101, 2008.

  20. Levy, BD, Lukacs, NW, Berlin, AA, Schmidt, B, Guilford, WJ, Serhan, CN, Parkinson, JF. Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB Journal. 2007 Dec; 21(14): 3877-84.

  21. Gyurko R, Herrera BS, Ohira T, Gao L, Omori K, Yang R, Muscara MN, Serhan CN, Van Dyke TE. An endogenous regulator of inflammation, resolvin E1 modulates osteoclast differentiation and bone resorption. Br J Pharmacol. (accepted).

  22. Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD. Resolvin regulates interleukin-23, interferon-gamma and lipoxin A4 to promote resolution of allergic airway inflammation. Nat Immunol. (accepted).

  23. Merched A, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: Evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. (accepted)
 

Reviews and Chapters

  1. Yacoubian S, Serhan CN. New endogenous anti-inflammatory and pro-resolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol. 2007; 3:570-79.

  2. Serhan CN, Chiang N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol. 2007; 153:S200-S215 (published on-line October 29; doi: 10.1038/sj.bjp.0707489).

  3. Serhan CN, Lu Y, Hong S, Yang R. Mediator lipidomics: search algorithms for eicosanoids, resolvins and protectins. In: Brown HA, ed. Lipidomics and Bioactive Lipids: Mass-Spectrometry-Based Lipid Analysis. San Diego: Elsevier, 2007:275-317 (Methods in Enzymology, vol. 432).

  4. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: pro-resolving lipid mediators and their potential therapeutic impact. Nat Rev Immunol. 2008; 8:249-61 (issue cover).

  5. Louis NA, Campbell E, Colgan SP. Methods and protocols to study neutrophil adhesion and chemotaxis. Chapter 17. In: Quinn M, DeLeo F and Bokoch G, editors. Neutrophil Methods and Protocols. Methods in Molecular Biology. Humana Press, Totowa, NJ. 2007.

  6. Taylor CT, Colgan SP.Hypoxia and gastrointestinal disease. J Mol Med. 2007 Dec;85(12):1295-300.

  7. Van Dyke TE. Control of Inflammation and Periodontitis. Periodontol 2000 (45): 158-166, 2007.

  8. Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G. The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. J Clin Periodontol. Feb;35(2):89-105 2008.

  9. Haworth, O, Levy, BD. Endogenous Lipid Mediators in the Resolution of Airway Inflammation.  European Respiratory Journal. 2007 Nov; 30(5): 980-92.