Serhan Lab Publications

2008-present 
 

Original Reports 

  1. Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CN. Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008; 180:3512-19.

  2. Poulsen RC, Gotlinger KH, Serhan CN, Kruger MC. Identification of inflammatory and pro-resolving lipid mediators in bone marrow and their profile alteration with ovariectomy and omega-3 intake. Am J Hematol. 2008; 83:437-45 (doi: 10.1002/ajh.21170).

  3. Petasis NA, Keledjian R, Sun Y-P, Nagulapalli KC, Tjonahen E, Yang R, Serhan CN. Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorg Med Chem Lett. 2008; 18:1382-87 (doi:10.1016/j.bmcl.2008.01.013).

  4. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CN. Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood 2008; 112:848-55 (prepublished online 5/14/08; doi: 10.1182/blood-2007-11-122598).

  5. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS ONE 2008; 3:e1879.

  6. Merched A, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: Evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008; 22:3595-606 (Epub 6/17/08; doi: 10.1096/fj.08-112201).

  7. Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD. Resolvin E1 regulates interleukin-23, interferon-gamma and lipoxin A4 to promote resolution of allergic airway inflammation. Nat Immunol. 2008; 9:873-79 (published on-line 6/22/08; doi: 10.1038/ni.1627).

  8. Malawista SE, de Boisfleury Chevance A, van Damme J, Serhan CN. Tonic inhibition of chemotaxis in human plasma. Proc Natl Acad Sci USA 2008; 105:17949-54 (published on-line 11/7/08; doi:10.1073/pnas.0802572105).

  9. Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko R. An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Br J Pharmacol. 2008; 155:1214-23 (Epub Sept 22).

  10. Chen M, Divangahi M, Gan H, Shin DS, Hong S, Lee DM, Serhan CN, Behar SM, Remold HG. Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death. J Exp Med. 2008; 205:2791-801 (Epub Oct 27).

  11. Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN. Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol. 2008; 181:8677-87.

  12. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent anti-inflammatory and pro-resolving actions. J Exp Med. 2009; 206:15-23 (published online 12/22/08; doi: 10.1084/jem.20081880).

  13. Zurier RB, Sun Y-P, George KL, Stebulis JA, Rossetti RG, Skulas A, Judge E, Serhan CN. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous pro-resolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009; 23:1503-9 (published online 1/5/09; doi: 10.1096/fj.08-118323).

  14. Spite M, Summers L, Porter TF, Srivastava S, Bhatnagar A, Serhan CN. Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Brit J Pharmacol. 2009; 158:1062-73 (published online 5/5/09; doi: 10.1111/j.1476-5381.2009.00234.x).

  15. Jin Y, Arita M, Zhang Q, Saban DR, Chauhan SK, Chiang N, Serhan CN, Dana R. Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Ophthalmol Vis Sci. 2009; 50:4743-4752 (published on-line 4/30/09; doi:10.1167/iovs.08-2462).

  16. Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma T. Resolvin E1, an endogenous lipid mediator derved from eicosapentaenoic acid, prevents dextran sulfate sodium induced colitis. Inflamm Bowel Dis. 2010; 16:87-95 (published on-line 7/1/09; doi: 10.1002/ibd.21029).

  17. El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JG. 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. Am J Respir Crit Care Med. 2009; 180:311-19 (Epub May 29; doi:10.1164/rccm.200810-1601OC).

  18. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 2009; 461:1287-91.

  19. Sun Y-P, Tjonahen E, Keledjian R, Zhu M, Yang R, Recchiuti A, Pillai PS, Petasis NA, Serhan CN. Anti-inflammatory and pro-resolving properties of benzo-lipoxin A4 analogs. Prostaglandins Leukot. Essent. Fatty Acids 2009; 81:357-366 (Epub 10/21/09; doi: 10.1016/j.plefa.2009.09.004).

  20. Gleissman H, Yang R, Martinod K, Lindskog M, Serhan CN, Johnsen JI, Kogner P. Docosahexaenoic acid metabolome in neural tumors: Identification of cytotoxic intermediates. FASEB J. 2010; 24:906-15 (published on-line 11/04/09; doi: 10.1096/fj.09-137919).

  21. Ohira T, Arita M, Omori K, Recchiuti A, Van Dyke TE, Serhan CN. Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem. 2010; 285:3451-61 (Epub Nov. 11, 2009; doi: 10.1074/jbc.M109.044131).

  22. Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Petasis NA, Serhan CN, Bazan NG. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot. Essent. Fatty Acids 2010; 82:27-34 (Epub Nov. 18, 2009; doi: 10.1016/j.plefa.2009.10.010).

  23. Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee C-H, Yang R, Petasis NA, Serhan CN. Resolvin D1 binds human phagocytes: Evidence for pro-resolving receptors. Proc Natl Acad Sci USA 2010; 107:1660-5 (Epub Jan. 4; doi: 10.1073/pnas.0907342107).

  24. Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai S-Y, Ye K, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci. USA 2010; 107:3546-51 (Epub Feb. 8; doi: 10.1073/pnas.0914351107).

  25. Planagumà A, Pfeffer MA, Rubin G, Croze R, Uddin M, Serhan CN, Levy BD. Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. Mucosal Immunol. 2010; 3:270-9 (Epub Feb 3; doi: 10.1038/mi.2009.141).

  26. Xu Z-Z, Zhang L, Liu T, Park J-Y, Berta T, Yang R, Serhan CN, Ji R-R. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nat Med. 2010; 16:592-7 (Epub April 11; doi:10.1038/nm.2123). Selected by the Faculty of 1000 to be in the top 2% of published articles in biology and medicine.

  27. Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AHK, Pande R, Creager MA, Serhan CN, Conte MS. Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. Am J Pathol. 2010, 177:2116-23 (Epub Aug 13; doi: 10.2353/ajpath.2010.091082).

  28. Fredman G, Van Dyke TE, Serhan CN. Resolvin E1 regulates ADP activation of human platelets. Arterioscler Thromb Vasc Biol. 2010; 30:2005-13 (Epub Aug 11; doi: 10.1161/ATVBAHA.110.209908).

  29. Levy BD, Zhang Q-y, Bonnans C, Primo V, Reilly JJ, Perkins DL, Liang Y, Arnaout MA, Nikolic B, Serhan CN. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot. Essent. Fatty Acids 2011; 84:43-50 (Epub Sept 23, 2010; doi: 10.1016/j.plefa.2010.09.002).

  30. Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CN. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. FASEB J 2011; 25:544-60 (Epub Oct 18, 2010; doi: 10.1096/fj.10-169599).

  31. Schif-Zuck S, Gross N, Assi S, Rostoker R, Serhan CN, Ariel A. Satiated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids. Eur J Immunol. 2011; 41:366-379 (Epub Dec 1, 2010; doi: 10.1002/eji.201040801). Selected by the Faculty of 1000 to be in the top 2% of published articles in biology and medicine.

  32. Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest. 2011; 121:569-81 (Epub Jan 4; doi: 10.1172/JCI42545). Commentary: http://www.lipidmaps.org/update/2011/110201/full/ lipidmaps.2011.2.html

  33. Huang L, Wang C-F, Serhan CN, Strichartz G. Enduring prevention and transient reduction of post-operative pain by intrathecal resolvin D1. Pain 2011; 152:557-65 (Epub Jan 19; doi: 10.1016/j.pain.2010.11.021).

  34. Pillai PS, Leeson S, Porter TF, Owens CD, Kim JM, Conte MS, Serhan CN, Gelman S. Chemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients. Inflammation 2012; 35:98-113 (Epub Feb 1, 2011; doi: 10.1007/s10753-011-9294-8).

  35. Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CN. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by Resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011; 186:4455-66 (Epub Feb 28; doi: 10.4049/jimmunol.1000833).

  36. Merched AJ, Serhan CN, Chan L. Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis. J Nutrigenet Nutrigenomics 2011, 4:12-24 (doi: 10.1159/000326890).

  37. Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN. Humanized nano pro-resolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol. 2011 (Cutting Edge), 186:5543-47 (Epub April 1; doi:10.4049/jimmunol.1003865).

  38. Palmer CD, Mancuso CJ, Weiss JP, Serhan CN, Guinan EC, Levy O. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol. 2011; 90:459-70 (Epub June 7; doi: 10.1189/jlb.0311145).

  39. Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA. Novel proresolving aspirin-triggered DHA pathway. Chem Biol. 2011; 18:976-987 (doi: 10.1016/j.chembiol.2011.06.008).

  40. Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011; 286:31532-41 (Epub July 12; doi: 10.1074/jbc.M111.237990). Highlighted in the Nature-LIPID MAPS Lipidomics Gateway (www.lipidmaps.org), October 2011.

  41. Fredman G, Oh SF, Ayilavarapu S, Hasturk H, Serhan CN, Van Dyke, TE. Impaired phagocytosis in localized aggressive periodontitis: Rescue by resolvin E1. PLoS ONE 2011; 6:e24422.

  42. Park C-K, Lü N, Xu Z-Z, Liu T, Serhan CN, Ji R-R. Resolving TRPV1 and TNF--mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci. 2011; 31:15072-15085 (issue cover).

  43. Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TTH, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King M-C, Serhan CN, Ramakrishnan L. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 2012; 148:434-46.

  44. Park C-K, Xu Z-Z, Liu T, Lü N, Serhan CN, Ji R-R. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: Distinct roles of resolvin D1, D2, and E1. J Neurosci. 2011; 31:18433-18438.

  45. Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KE. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis via acyl-CoA synthetase 1. Proc Natl Acad Sci USA 2012; 109:E715-24 (Epub 1/17/12; doi: 10.1073/pnas.1111600109).

  46. Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA. Macrophage pro-resolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012; 26:1755-65 (Epub 1/17/12; doi: 10.1096/fj.11-201442).

  47. Petasis NA, Yang R, Winkler JW, Zhu M, Uddin J, Bazan NG, Serhan CN. Stereocontrolled total synthesis of neuroprotectin D1/protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Lett. 2012; 53:1695-98 (published online: http://dx.doi.org/10.1016/j.tetlet.2012.01.032).

  48. Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CN. Resolvin E2 formation and impact in inflammation-resolution. J Immunol. 2012; 188:4527-34 (Epub 3/26/12; doi: 10.4049/jimmunol.1103652). Featured “In This Issue” in The Journal of Immunology.

  49. Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 2012; 484:524-28 (doi: 10.1038/nature11042). Featured in “Research Highlights”, Nat Rev Drug Discov. 2012; 11:441 (doi: 10.1038/nrd3760)

  50. Krishnamoorthy S, Recchiuti A, Chiang N, Fredman G, Serhan CN. Resolvin D1 receptor stereoselectivity and regulation of inflammation and pro-resolving microRNAs. Am J Pathol. 2012; 180:2018-27 (Epub 3/23/12; doi: 10.1016/j.ajpath.2012.01.028).

  51. Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M. Resolvin D1 limits polymorphonuclear leukocytes recruitment to inflammatory loci: receptor dependent actions. Arterioscler Thromb Vasc Biol. 2012; 32:1970-78 (Epub 4/12/12; 10.1161/ATVBAHA.112.249508 [doi]).

  52. Bazan NG, Eady TN, Khoutorova L, Atkins KD, Hong S, Lu Y, Zhang C, Jun B, Obenaus A, Fredman G, Zhu M, Winkler JW, Petasis NA, Serhan CN, Belayev L. Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol. 2012; 236:122-30 (Epub 4/19/12; 10.1016/j.expneurol.2012.04.007 [doi]).

  53. Ramon S, Gao F, Serhan CN, Phipps RP. Specialized proresolving mediators enhance human B cell differentiation to antibody secreting cells. J Immunol. 2012; 189:1036-42 (Epub June 18, 10.4049/jimmunol.1103483 [doi]).

  54. Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol. 2012; 189:1983-91 (Epub Jul 16; 10.4049/jimmunol.1101665 [doi]).

  55. Clària J, Dalli J, Yacoubian S, Gao F, Serhan CN. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. J Immunol. 2012; 189:2597-605 (Epub Jul 27; 10.4049/jimmunol.1201272 [doi]).

  56. Giera M, Ioan-Facsinay A, Toes R, Gao F, Dalli J, Deelder AM, Serhan CN, Mayboroda OA. Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim Biophys Acta 2012; 1821:1415-24 (Epub Jul 24; doi: 10.1016/j.bbalip.2012.07.011).

  57. Dalli J, Serhan CN. Specific lipid mediator signatures of human phagocytes: Microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 2012; Epub Aug 17; doi: 10.1182/blood-2012-02-413021.

  58. Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid A. Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot. Essent. Fatty Acids 2012; Epub Sep 10; doi: 10.1016/j.plefa.2012.08.003.

  59. Fredman G, Li Y, Dalli J, Chiang N, Serhan CN. Self-limited versus delayed resolution of acute inflammation: Temporal regulation of pro-resolving mediators and microRNA. Sci Rep. 2012; 2:639 (Epub Sep 6; doi: 10.1038/srep00639).

  60. Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia D. Microfluidic chambers for monitoring leukocyte trafficking: modulation by humanized nano pro-resolving medicines. Proc Natl Acad Sci USA 2012; in press.


Reviews and Educationally Relevant Publications  

  1. Serhan CN, Chiang N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol. 2008; 153(Suppl. 1):S200-S215 (published on-line October 29; doi: 10.1038/sj.bjp.0707489).

  2. Serhan CN, Yacoubian S, Yang R. Anti-inflammatory and pro-resolving lipid mediators. In: Abbas AK, Galli SJ, Howley PM, eds. Annu Rev Pathol Mech Dis. 2008; 3:279-312.

  3. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008; 8:349-61 (issue cover).

  4. Serhan CN. Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators. Prostaglandins Leukot. Essent. Fatty Acids 2008; 79:157-63 (published on-line 11/11/08; doi: 10.1016/j.plefa.2008.09.012).

  5. Chiang N, Serhan CN. Lipoxin A4 receptors. In: Alexander SPH, Mathie A, Peters JA, eds. Guide to Receptors and Channels, 3rd ed. Br J Pharmacol. 2008; 153 Suppl 2:S1-S209.

  6. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and pro-resolving mediators. J Periodontol. (Workshop on Inflammation Supplement) 2008; 79 (8 Suppl):1520-6.

  7. Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM. International Union of Basic and Clinical Pharmacology LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev. 2009; 61:119-61 (Epub June 4; doi: 10.1124/pr.109.001578).

  8. Chiang N, Serhan CN. Lipoxin A4 receptors. In: Alexander SPH, Mathie A, Peters JA, eds. Guide to Receptors and Channels, 4th ed. Br J Pharmacol. 2009; 158 Suppl 1:S1-S254.

  9. Serhan CN. Systems approach to inflammation-resolution: identification of novel anti-inflammatory and pro-resolving mediators. J Thromb Haemost. 2009; 7 Suppl 1:44-48. Selected by the Faculty of 1000 to be in the top 2% of published articles in biology and medicine.

  10. Serhan CN, Aliberti J. Novel anti-inflammatory and pro-resolution lipid mediators in induction and modulation of phagocyte function. In: Russell DG, Gordon S, eds. Phagocyte-Pathogen Interactions: Macrophages and the Host Response to Inflammation. Washington: ASM Press, 2009:267-80.

  11. Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins: pro-resolving mediators in anti-inflammation and resolution. In: Bradshaw RA, Dennis EA, eds. Handbook of Cell Signaling, 2nd ed. San Diego: Elsevier, 2009.

  12. Bazan NG, Calandria JM, Serhan CN. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. 2010; 51:2018-31 (Epub April 9; doi: 10.1194/jlr.R001131).

  13. Bannenberg G, Serhan CN. Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim Biophys Acta 2010; 1801:1260-73 (Epub Aug 10; doi:10.1016/ j.bbalip.2010.08.002).

  14. Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010; 107:1170-84.

  15. Serhan CN. Novel lipid mediators resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol. 2010; 177:1576-91 (Epub Sept. 2; doi: 10.2353/ajpath.2010.100322). Selected by the Faculty of 1000 to be in the top 2% of published articles in biology and medicine.

  16. Norling LV, Serhan CN. Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination. Gunnar Birke Symposium 2010. J Intern Med. 2010; 268:15-24 (published online 5/28/2010; doi: 10.1111/j.1365-2796.2010.02235.x). Selected by the Faculty of 1000 to be in the top 2% of published articles in biology and medicine.

  17. Serhan CN, Haeggström JZ. Lipid mediators in acute inflammation and resolution: eicosanoids, PAF, resolvins and protectins. In: Serhan CN, Ward P, Gilroy D, eds. Fundamentals of Inflammation. New York: Cambridge University Press, 2010:153-74.

  18. Bannenberg G, Serhan CN. A novel genus of specialized anti-inflammatory and pro-resolution lipid mediators. In: Arnason BG, ed. The Brain and Host Defense. San Diego: Elsevier, 2010:37-57 (NeuroImmune Biology, vol. 9, Berczi I, Szentiványi A, eds.).

  19. Serhan CN, Krishnamoorthy S, Recchiuti A, Chiang, N. Novel anti-inflammatory – pro-resolving mediators and their receptors. Curr Top Med Chem. 2011; 11:629-47 (Epub Jan 25).

  20. Serhan CN. The resolution of inflammation: the devil in the flask and in the details. FASEB J. 2011; 25:1441-48 (doi: 10.1096/fj.11-0502ufm).

  21. Oh SF, Vickery TW, Serhan CN. Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta 2011; 1811:737-47 (Epub June 16; doi: 10.1016/j.bbalip.2011.06.007).

  22. Fredman G, Serhan CN. Specialized pro-resolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011; 437:185-97 (Epub June 28; doi: 10.1042/BJ20110327).

  23. Spite M, Serhan CN. Lipid signatures of unstable atheromas: Fossils or a step toward personalized lipidomics-metabolomics? Circ Cardiovasc Genet. 2011; 4:215-17 (doi: 10.1161/CIRCGENETICS.111.960344).

  24. Bäck M, Dahlén, S-E, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati, GE. International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene receptor nomenclature, distribution, and pathophysiological functions. Pharmacol Rev. 2011; 63:539-84 (doi:10.1124/pr.110.004184).

  25. Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Thematic issue on Lipid Biochemistry, Metabolism, and Signaling. Chem Rev. 2011; 111:5922-43 (Epub July 18; doi: 10.1021/cr100396c).

  26. Campbell EL, Serhan CN, Colgan SP. Antimicrobial aspects of inflammatory resolution in the mucosa: A role for proresolving mediators. J Immunol. 2011; 187:3475-81.

  27. Greene ER, Huang S, Serhan CN, Panigrahy D. Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat. (WEC Special Issue) 2011; 96:27-36 (Epub Aug 16; doi: 10.1016/j.prostaglandins.2011.08.004).

  28. Ji R-R, Xu Z-Z, Strichartz G, Serhan CN. Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci. 2011; 34:599-609 (Epub Sep 29; doi: 10.1016/j.tins.2011.08.005).

  29. Yang R, Chiang N, Oh SF, Serhan CN. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol. 2011; 95:14.26.1-14.26.26.

  30. Serhan CN. Resolvins and protectins: specialized pro-resolving mediators in inflammation and organ protection: metabolomics of catabasis. In: Erdman J, Oria M, Pillsbury L, eds. Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel. Washington, DC: The National Academies Press, 2011:347-69.

  31. Serhan CN, Godson C. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease. In: Goligorsky MS, ed. Regenerative Nephrology. San Diego: Elsevier, 2011:69-92.

  32. Chiang N, Serhan CN. Leukotriene, lipoxin, oxoeicosanoid and resolvin E1. In: Alexander SPH, Mathie A, Peters JA, eds. Guide to Receptors and Channels, 5th ed. Br J Pharmacol. 2011; 164 Suppl 1:S74-S75.

  33. Ariel A, Serhan CN. New lives given by cell death: macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation. Front Immun. 2012; 3:4. doi: 10.3389/fimmu.2012.00004.

  34. Shinohara M, Mirakaj V, Serhan CN. Functional metabolomics reveals novel active products in the DHA metabolome. Front Immun. 2012; 3:81 (doi: 10.3389/fimmu.2012.00081).

  35. Levy BD Vachier I, Serhan CN. Resolution of inflammation in asthma. Clin Chest Med. 2012; 33:559-70 (Epub Jul 25; doi: 10.1016/j.ccm.2012.06.006).

  36. Abumrad N, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. Moving beyond “good fat, bad fat” – the complex roles of dietary lipids in cellular function and health: session abstracts. EB 2011, Washington DC, Session on Functional Foods for Health Promotion: sponsored by the Dietary Lipids Committee of the ILSI in cooperation with the ASN. Adv. Nutr. 2012; 3:60-68.

  37. Fredman G, Serhan CN. Specialized pro-resolving lipid derived fatty acid mediators: wiring the circuitry of effector immune homeostasis. In: Larjava H, ed. Oral Wound Healing: Cell Biology and Clinical Management. Ames, IA: JohnWiley & Sons, 2012:57-79.

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